New research reveals that individuals who come off new slimming jabs like Wegovy and Mounjaro can put back on shed pounds far faster than those who stop conventional lifestyle programs.
Published data in a major health publication points out that while obese people can lose a large proportion of their body weight while undergoing treatment, the weight comes back at an average rate of 0.8 kg per month once they quit.
"People using such drugs need to be informed of the danger of rapid rebound weight gain when the therapy ends," warns lead investigator Dr. Susan Jebb.
This pace of recovery suggests a return to original mass within about 18 months.
Weighing Approaches
The analysis, which reviewed dozens of studies involving over 9,000 of participants, contrasted the outcomes of the injectable medications with other pills.
Scientists note that people who shed pounds through lifestyle changes alone typically experience a slower weight regain—around 100 grams monthly—post-intervention.
Explaining the Quick Regain
Experts suggest the mode of action of the drugs is key to understanding the heightened regain.
GLP-1 drugs copy a body's own chemical called glucagon-like peptide-1, which controls feelings of fullness.
"Long-term administration of GLP-1 concentrations far above than normal might result in the system to generate a reduced amount of its own natural hormone, and may also lessen responsiveness to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this hormone supplement means hunger is uncontrolled, making binge eating a significant risk."
A Chronic Disease?
Medical guidelines suggest the jabs for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Professionals argue that, due to the likelihood of relapse, the treatment is often ongoing.
This perspective is supported by drug manufacturers, who state that the findings "underscore the persistent nature of excess weight," comparing it to managing diseases like hypertension.
User Accounts
People who have come off the jabs report a powerful resurgence of cravings.
"I experienced a switch flipping and you become extremely hungry," recalled one woman.
This challenge is exacerbated if patients have not developed permanent dietary or behavioural changes during therapy.
Significant Adoption
Figures indicate that millions of adults in the UK have used these injections in the past year, with interest being substantial.
- Use is more common among women than males.
- The 40s and 50s demographic shows the highest level of interest.
- Many obtain the medications through private prescriptions rather than the NHS.
Finally, clinicians emphasize that while these medications are potent agents for shedding pounds, they are not a magic solution and lasting health benefits hinges on ongoing lifestyle changes.
